Clordiazepóxido is a hypnotic drug derived from Benzodiacepinas Posee properties of Sedation, ansiolisis and muscular relaxation .
The clordiazepóxido one was first Benzodiazepina in being synthesized and being arranged to its commercialization. in the middle of was open pie accidentally by Leo Sternbach 50s, and commercialized by Roche Pharmaceuticals in 1960 . has one moderate Elimination half-life to long.
Sternbach would later develop Diazepam, sold by Roche from 1963 . Soon other companies would develop many other varieties of this drug.
As the prescriptions of benzodiacepinas were in quick ascent at the end of 60s and in 70 years, the problem of dependancy to these drugs began to arise. Nevertheless, the clordiazepóxido one is still an effective treatment for the patients who undergo of pictures of acute Anxiety . Still one takes place and it prescribes nowadays, along with an ample variety of benzodiazepinas, all with similar characteristics.
Mechanism of Action
It is thought that the clordiazepóxido one acts on the receivers GABA type To, producing an inhibiting effect similar to the one of others Benzodiazepinas
The clordiazepóxido one blocks the cerebral activity build-up electrical originating of the stimulation of reticular Formation in Trunk of encéfalo .
In animal studies an action has been seen on límbico System of Brain, which has to do with the emotional effects of the drug. These effects are essentially the diminution of the fear and the aggression.
The clordiazepóxido one is indicated for the treatment of:
Overdose of clordiazepóxido is considered a emergencia medical and requires, generally, the immediate attendance of medical personnel. Antidote for a clordiazapóxido overdose of (as with any other benzodiazepina) is Flumazenil .